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Zinman B, Hoogwerf BJ, Duran GS, Milton DR, Giaconia JM, Kim DD et al
Tirzepatide is administered as a once-weekly subcutaneous injection, with dosing typically initiated at 2.5 mg for 4 weeks (a non-therapeutic initiation dose to improve tolerability), then increased every 4 weeks to reach a therapeutic dose of 5-15 mg weekly based on response and tolerability
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Since semaglutide is a different molecule, antibodies against tirzepatide do not cross-react with it, and the formulation differences mean the local immune response may be entirely different