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PRM, parameter response mapping
The concentration of TSNAs differs among products, with higher levels correlating to increased cancer risks
The present study, as part of the Global Burden of Diseases, Risk Factors, and Injuries Study (GBD) 2020, re-estimated the continuous doseresponse relationships (the mean risk functions and associated uncertainty estimates) between current smoking and 36 health outcomes (Supplementary Table 1) by identifying input studies using a systematic review approach and employing a meta-analytic method 28
User surveys suggested that the benefits of using of e-cigarettes by smokers included less cigarette consumption, help with smoking cessation, and reduced craving and withdrawal symptoms [61, 62]
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