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4.4 Representative evidence base: what has been shown and what remains uncertain Representative studies report improved intracellular delivery and enhanced anticancer effects of MSN-loaded phenolics compared with free compounds, including curcumin-loaded MSNs (Table 1 to improve manuscript usability and to make the translational signal of each study explicit
International Journal of Molecular Sciences, 20(15), 3618
Expected timelines for improvement vary by condition and individual
This distinction was necessary to evaluate the specific effects of IF on the study outcomes
This system regulates extracellular glutamate concentrations through non-vesicular release, establishing a vital feedback loop: the released glutamate activates presynaptic group II metabotropic receptors (mGluR2/3), which in turn inhibit vesicular glutamate release and offer protection against N-methyl-D-aspartate receptor (NMDAR)-mediated excitotoxicity (Figure 2) [8,69,70,71]
