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Each e-liquid is composed of just four components: Propylene glycol (PG) - a viscous, colourless liquid that produces a throat hit Vegetable glycerin (VG) - a thick, sweet liquid that produces clouds of vapour Food-grade flavourings Nicotine The most realistic e-cigarettes contain a 50/50 ratio of PG and VG as they balance throat hit and vapour production in a way that most closely resembles the experience of smoking a cigarette

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Weve succeed. The increased cigarette and other tobacco taxes have also brought in hundreds of millions of dollars in new revenue over the years

Since randomized trials and prospective cohort designs on this topic are not practical given the ethical issues and the need for a large study population with extended follow-up, there is a need for well-designed retrospective studies despite the inherent limitations from recall bias and unmeasured confounding factors

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