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Exposure to benzene, a known human carcinogen regularly monitored by the US Environmental Protection Agency (EPA) under federal and state toxic substances regulations, can occur through breathing contaminated air, skin contact with benzene-containing materials, or, less commonly, ingestion of contaminated water or soil

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44 Our data provide a mechanistic explanation for how CS induces mitophagy-driven necroptosis and further support the fact that the dysregulated sphingolipid metabolism is implicated in the pathogenesis of structural cell injury in COPD

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