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doi: 10.1128/MCB.00090-14 356 AbeFDaffernerAJDonkorMWestphalSNScholarEMSolheimJCet al

NASH can progress to cirrhosis, which is characterized by the formation of fibrous bands and regenerative nodules throughout the liver

reported that in a virus-induced fibrosis model, elevated Kyn exacerbated IL-17Adependent inflammation and collagen accumulation, suggesting that Kyn/AhR signaling may have pro-fibrotic effects under certain conditions [118]