Photoaging is caused not only by increased degradation of collagen by various MMPs, serine and other proteases but also by decreased collagen production by fibroblasts (1)
For example, L-ascorbic acid, a form of vitamin C found in many skin care products, degrades when it is exposed to heat, a high pH or sunlight, she said which can happen during transit and storage. And then theres the question of sufficient penetration into the skin barrier to allow Vitamin C to do what it needs to do to truly promote your skin health
Talanta 72(5):16981703 Guo H, Xue K, Yan L (2012) Resonance Rayleigh scattering spectral method for determination of urinary 8-hydroxy-2-deoxyguanosine using gold nanoparticles as probe
Liposomal formats are the preferred choice for daily home use because they offer high bioavailability without the need for medical procedures
(Source 7) One small study showed that drinking 5 cups of coffee per day increased glutathione levels by 16% compared to a control group