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The differences in receptor effects of various antipsychotics can explain many of their toxicities and are shown to be consistently associated with high D2 potency (2)

Biomed Pharmacother 2018;108:952-62.ArticlePubMed 14

It names dehydration, shifting blood glucose levels, and electrolyte changes during the first one to two weeks of therapy as the likely contributors, layered on top of the slowed gastric emptying and satiety signaling the drugs produce

This is usually a metabolic response and often resolves as intake, weight, and hormone signaling stabilize

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