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The FDA is currently evaluating reports of suicidal thoughts in patients taking GLP-1 receptor agonists, though no definitive causal relationship has been established to date

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Unlike peptide, the binding of compound 2 and other small molecule modulators require a complementary conformation of the ECD for ligand recognition, such that the N-terminal -helix of the compound 2GLP-1RG s deeply inserted to the orthosteric binding pocket as opposed to other GLP-1R structures (Fig