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Patients should be counseled to contact their healthcare provider if they experience any of the following: Severe or persistent gastrointestinal symptoms including intractable nausea or vomiting lasting more than 24-48 hours, inability to maintain adequate oral hydration, severe abdominal pain (particularly if localized to the upper abdomen or radiating to the back), or signs of gastrointestinal bleeding such as bloody or black stools

Reduced joint pain from estrogen means more ability to exercise

S.AugustinR.et al (2018)

What Is Semaglutide Semaglutide is a GLP-1 (glucagon-like peptide-1) receptor agonist that was initially developed to treat type 2 diabetes

Two-sided P values of 0.05 were considered to indicate statistical significance