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Nicotine vaping products as a harm reduction tool among smokers: Review of evidence and implication for pharmacy practice Daniel Erku, Coral Gartner, Kylie Morphett, Centaine Snoswell, Kathryn Steadman Research in Social and Administrative Pharmacy 2

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Understanding what causes it is the first step toward managing it safely and comfortably

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Neurotherapeutics Key mechanisms behind this suppression: CB1 receptor activation directly inhibits REM-promoting neurons THC increases slow-wave sleep (SWS) at the expense of REM stages The brain treats THC-induced sleep as "compromised quality," prioritizing restoration over dreaming Tolerance develops with regular use, worsening the REM suppression effect over time What Is REM Rebound and Why Does It Happen When You Quit Weed