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Overall, individuals with diabetes face a higher risk of infections compared to the general population, with pneumonia being a leading cause of mortality among them [176, 177]

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The aim of the therapy is to replace the glucocorticoids (with hydrocortisone or dexamethasone) and in some cases mineralocorticoids (with fludrocortisone)

NF-kB is a signaling protein that drives production of myriad inflammatory cytokines including interleukin-1b (IL-1b) and interleukin-6 (IL-6)

Despite some reports on the similarities between senescence and eryptosis at the morphological level [67], intracellular Ca 2+ elevation [74], Ca 2+ -driven activation of Gardos channels [70], PS exposure [76], or ROS contribution [71], senescence of erythrocytes cannot be considered an RCD of these cells and should be clearly distinguished from eryptosis