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Graphical Abstract 1 Introduction Stroke is a neurological disease with high disability and mortality rates, and has risen to become the second leading cause of death worldwide ( 2+ ) and an increased level of reactive oxygen species (ROS), leading to myocardial injury and cardiomyocyte apoptosis ( 2 Activation of the SNS after AIS Some specific regions of the forebrain cortex, limbic lobe, and brainstem are collectively involved in central sympathetic nervous (CSN) regulation

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If the liver is exposed to an excess of APAP, however, these detoxification processes are overwhelmed, and APAP is instead metabolized by the cytochrome P450 enzyme CYP2E1 into the highly reactive and toxic metabolite NAPQI 4