Apart from the recognised factors that affect substance use disorders in general, examination of the particular association between smoking and schizophrenia raises three main possible hypotheses: first, patients smoke at an increased frequency because smoking ameliorates some of the symptoms of schizophrenia and side-effects of medication second, smoking causes an increased predisposition to develop psychosis third, common genetic risk factors make some individuals more vulnerable to developing schizophrenia and nicotine dependence
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More studies are needed to address other questions, such as the risk of serious side effects when using bupropion, and to clarify the most effective dosing strategy
The consumer-side welfare losses are not easy to measure because data on concentration in liquid and pre-regulation are not publicly available
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