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There is evidence female vascular biology (hormone-modulated) can react in ways that magnify some of these smoking-induced cardiovascular harms, which helps explain higher relative CHD risk in female smokers

Other animal studies have found that chronic secondhand smoke exposure of mice altered the gut microbiome as well as gene and protein expression in the colon

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Among these, flavonoids in tobacco leaves are synthesized through pathways such as flavone and flavonol biosynthesis, as well as the phenylpropanoid pathway, under the action of various enzymes, including flavonol synthase (FLS) and phenylalanine ammonia-lyase (PAL) [15]

The experiments examining the impact of carbon loading on toxicant yields confirmed that substantial decreases in the emissions of mainstream volatile constituents can be obtained at high HAC loading