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When the medication is discontinued, appetite regulation returns toward baseline levels, and without the medication's effects, maintaining the same caloric restriction becomes more difficult

The new use of Wegovy is targeted to people with established cardiovascular disease meaning a prior heart attack, prior stroke, or peripheral arterial disease and either obesity or overweight

Contrave (bupropion/naltrexone) is FDA-approved for chronic weight management in adults with obesity, or overweight and a weight-related health condition

doi: 10.1016/j.taap.2018.09.030

Those using higher daily doses sometimes split intake across morning and pre-workout timings