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The most common side effects of metformin are gastrointestinal (GI), including diarrhea, nausea, and abdominal discomfort

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Although clinical studies have not demonstrated overt systemic depletion of NAD(P) during GLP-1RA therapy, sustained reductions in nutrient inflow may influence precursor availability and turnover kinetics, particularly in metabolically stressed populations

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The answer is simple and direct: No, it is not