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The available studies differ in drug type, dose, indication, timing of exposure, comparator structure, and baseline maternal metabolic risk, and the number of exposed pregnancies remains insufficient to exclude uncommon but clinically important harms ( 4.5.3 Risk communication: clarifying uncertainty Current evidence is insufficient to classify GLP-1RAs as relatively safe during pregnancy, and they should certainly not be used as a first-line treatment for gestational obesity or diabetes simply due to their weight-loss benefits ( 4.6 Quality of life and psychology: benefits driven by symptom and weight improvement Quality of life (QoL) impairment in PCOS is frequently linked to weight distress, hirsutism, and infertility-related anxiety
[DOI] [PubMed] [Google Scholar] 111.Ivanov, A
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These drugs significantly reduced rates of #coloncancer (16% fewer cases) and #rectalcancer (28% fewer cases), among others like post-menopausal #breastcancer, #endometrialcancer, and #pancreaticcancer
