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Key Mechanisms Delta-wave sleep promotion Cortisol modulation LH release modulation Somatostatin interaction Endorphin system modulation Primary Research Areas Sleep architecture Insomnia Stress-related sleep disturbance Circadian regulation Pain modulation Key Research Findings Promoted delta-wave sleep in EEG studies without next-day sedation Normalized disturbed sleep patterns in chronic insomnia models Reduced ACTH and cortisol levels during stress in animal models Research Overview A nonapeptide first isolated in 1974 from the cerebral venous blood of rabbits during induced slow-wave sleep
Impairment of the HPA Axis The HPA axis regulates stress responses
While direct reproductive toxicity has been extensively documented, the mechanisms underlying heritable reproductive dysfunction represent an emerging frontier requiring intensive investigation ( Figure 3 )
APE1 was also one of the many non-regulatory proteins involved in cancer survival signaling pathways, and could be used as a therapeutic target in the treatment of multiple types of tumor cells [24]
