semaglutide and laxatives Constipation & Laxatives: Safety & Biomarker Context – PlexusDx Budget Ozempic': What to Know

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Your doctor will decide what dose of Wegovy to put you on based on your current Mounjaro dose

With the launch of @EliLillyandCo 's orforglipron (Foundayo) for #obesity, many clinicians are asking how to switch patients who are already on a #GLP1 like semaglutide: Evidence-informed TLDR: semaglutide 1.5-2.0 mg/wk orforglipron max dose for #weightloss If switching from sema 2.4 mg/wk, start orforglipron 9 mg/d one week after the last injection, increase to 14.5 mg in 4 weeks, then increase to 17.2 mg, assuming tolerability Counsel that 5% of weight lost may be regained with this switch for details: 1/ With the launch of @EliLillyandCo 's orforglipron (Foundayo) for #obesity, many clinicians are asking how to switch patients who are already on a #GLP1 like semaglutide: Evidence-informed TLDR: semaglutide 1.5-2.0 mg/wk orforglipron max dose for #weightloss If switching from sema 2.4 mg/wk, start orforglipron 9 mg/d one week after the last injection, increase to 14.5 mg in 4 weeks, then increase to 17.2 mg, assuming tolerability Counsel that 5% of weight lost may be regained with this switch for details: 1/ 2/ If a patient is on semaglutide inj, therapeutic equivalence could be informed by its phase 2 trial (thelancet.com/journals/lance), where sema 0.2-0.3 mg/d (1.4-2.1 mg/wk) resulted in ~11% #weightloss at 52 weeks3/ This 11.2-11.6^% weight loss is similar to the 11.2% #weightloss at 72 weeks in ATTAIN-1 with oforglipron 36 mg/d (nejm.org/doi/full/10.10)4/ If you want to switch from sema 2.4 mg/wk to orforglipron, the ATTAIN-MAINTAIN protocol offers a reasonable starting point: Sema 2.4 mg/wk orforglipron 12 mg (9 mg) x 4 wks 24 mg (14.5 mg) x 4 wks 36 mg (17.2 mg) Remember that available doses on the market are a5/5 Read the package insert for additional information: pi.lilly.com/us/foundayo-us And my orforglipron prescribing 101 at @Medscape medscape.com/viewarticle/pr It would be easier, have fewer side effects, and more efficacy just to prescribe them oral Wegovy Join the conversation

This is the critical threshold you must never exceed for any extended period

[1] [3] The precise mechanism underlying this heart rate elevation has not been fully established