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This also helps explain why romance can make escape harder

Prog Mol Biol Transl Sci 137, 183201

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In future studies, it would be of considerable interest to understand how sustained smoking behaviour, driven initially by hedonic experience may further develop into dependence (i.e., psychological or physical craving for nicotine following withdraw), where habit-inducing regions such as the insula and striatum might eventually become involved 55,56

These effects of the endocannabinoids depended on the presence of the worms cannabinoid receptors, but at the molecular level, the cannabinoid system in nematodes looks a lot like that in humans and other animals