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The quadruplet therapy may significantly improve long-term outcomes, according to J&J

Recent studies on the postmortem diagnosis of myocardial ischemia have immunohistochemically examined markers that either accumulate (such as fibronectin) or leak (such as troponin, myoglobin, and S100A1) into human myocytes during ischemic injury 10,14,28,29

Patient stratification probably matters more than any single drug choice, because the variable results likely conceal responder subgroups

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It may involve additional requirements or restrictions