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Exposure to nicotine ( in vivo ) can cause disturbances in spermatogenesis leading to a reduction in sperm count with subsequent male infertility [26, 27, 28, 29]

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Decreased sexual desire: Chronic smoking has been linked to lower libido and reduced sexual desire in men

Co-administration of an OCT2 inhibitor, cimetidine (300 mg four times daily), with varenicline (2 mg single dose) to 12 smokers increased the systemic exposure of varenicline by 29% (90% CI: 21.5%, 36.9%) due to a reduction in varenicline renal clearance

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