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Crockford, D., et al

Plant lignans and isoflavonoid phytoestrogens can decrease the conversion of androgens to estrone by inhibiting the cytochrome P450 enzyme aromatase, which can play a protective role in PCa

Steric hindrance from the increased side-chain volume of E14 Cagri and R17 Cagri promotes a shift of the -helix of Cagri away from ECL2 and a slight expansion of the peptide binding pocket at the extracellular side of the CTR TM domain, relative to those observed with rAmy/San385-bound AMYR complexes