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In propensity-matched analyses, semaglutide treatment was associated with lower rates of several cardiovascular outcomes than treatment with metformin, dipeptidyl peptidase-4 (DPP-4) inhibitors, and sodium-glucose cotransporter 2 (SGLT2) inhibitors
Dosing: Three times daily with meals Must take with or within 1 hour of meals containing fat Cost: Prescription (Xenical 120 mg): $100-$200/month OTC (Alli 60 mg): $40-$60/month Who Should Consider: Very few patients benefit May be option if all other medications contraindicated Extremely motivated to follow low-fat diet Dont mind frequent GI side effects Most weight loss specialists dont recommend orlistat due to poor effectiveness and troublesome side effects
Most people stabilize here or continue to the next tier depending on their response and tolerance
If more than five days have passed, the general guidance is to skip the missed dose and resume the following week
It suppresses appetite, delays gastric emptying, and enhances glucose-dependent insulin secretion
