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Physiology of peripheral and central GLP-1 signaling GLP-1 is a 30-amino acid peptide synthetized by enteroendocrine L cells of the small and large intestine, and also in the brain primarily by neurons of the nucleus tractus solitarius (NTS) within the caudal brainstem as a product of tissue-specific posttranslational cleavage of a larger precursor molecule preproglucagon (PPG)

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This damage leads to gene mutations and initiates early events associated with tumor initiation and progression

ACE inhibitors and angiotensin receptor blockers may alter the balance of RAS peptides and potentially interact with dihexa's mechanism