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Keywords: Glucagon-like peptide-1 agonists, Osteoarthritis, Rheumatoid arthritis, Psoriatic arthritis, System lupus erythematosus, Inflammation Core Tip: Growing evidence suggests that glucagon-like peptide-1 and its receptor agonists could be an effective treatment option not only for metabolic disorders but also for a range of autoimmune and inflammatory diseases

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In a second double-blind RCT, KET 0.5 mg/kg IV bolus followed by a 30 min infusion of 0.25 mg/kg/h increased mood and serum brain-derived neurotrophic factor, which is a marker of major depressive disorders and treatment response (Jiang et al., 2016)

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