Im pretty sure that even though we dont have the formal studies, we would see this similar result in which the combining of a GLP-1 plus a biologic is going to make patients do better in terms of skin and joints and overall health compared to a biologic alone
So, one of the things that people are interested in is this question of can you actually do too much
Glinos DA, Garborcauskas G, Hoffman P, Ehsan N, Jiang L, Gokden A, et al
Importantly, human trials mirror this finding: months of regular endurance exercise in sedentary seniors increased muscle mitochondrial DNA, oxidative enzyme activities (citrate synthase, COX) and electron transport chain function ( These adaptations can be quite robust
What I found in the trial data is that the dose escalation schedule matters a lot here