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Evidence-based medicine evaluation of electrophysiological studies of the anxiety disorders

Aroda reports institutional contracts from Amgen, Applied Therapeutics, AstraZeneca, Biomea, Boehringer Ingelheim, Corcept, Eli Lilly, Fractyl, Kailera, Novo Nordisk, Pfizer, Recordati, Rhythm and Servier, as well as consulting fees from Baim Institute for Clinical Research, Mediflix, Sanofi, and Roche

For a medication class where GI side effects are the leading reason patients discontinue, asking about psychological readiness up-front is a thoughtful clinical addition

After four weeks, the dose increases to 0.5 mg once weekly

The practical effect of longer duration is that trials can measure outcomes over weekly and multi week windows with consistent exposure, rather than focusing only on short time course endpoints