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The other two are comparative : He chose tirzepatide over pure GLP-1 (semaglutide) based partly on the SURPASS-CVOT trial, which showed tirzepatide performed at least as well as dulaglutide (a GLP-1 agonist) on cardiovascular outcomes, with a post-hoc analysis suggesting a 16% risk reduction on a broader six-component endpoint

Storage, handling, and practical considerations The practical side of using any injectable medication matters more than most people expect

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