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GLP-1 medications bind to GLP receptors to trigger the GLP-1 hormone to work

This adjustment phase is usually temporary as the body finds a new set point for its metabolism, but it can be disruptive in the early weeks of treatment

An estimated 3,160 participants are to receive once-weekly subcutaneous semaglutide (starting with 0.25 mg and the dose will be increased to 0.5 mg at 4 weeks and 1 mg at 8 weeks) for up to 5 years

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Concurrent medications and health status: Other medications may enhance or reduce peptide effects through pharmacokinetic or pharmacodynamic interactions