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The additional variation in this experiment likely arises from multiple other factors and design features of the commercial products that we are not able to control for like composition and quantity of additives, humectants or flavorants and tip filter size or composition

Moreover, these companies target vulnerable populations, including minors 18,19 , through direct advertising, free samples, and indirect strategies such as event sponsorship and tobacco imagery placement in media 18

Atherosclerosis, a condition where lipoproteins accumulate in arterial walls, is another metabolic disorder contributing to cardiovascular diseases (CVDs) (Shi et al., 2019)

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Thank you, Fiachra, for the work that you do