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Cleven AH, Sannaa GA, Briaire-de Bruijn I, Ingram DR, van de Rijn M, Rubin BP, et al

These interactions make DSIP a promising candidate for research on chronic pain and the mechanisms of dependence.DSIP and opioids, 1984, PMID 6548970

These results indicated that gingerols and shogaols have immunomodulatory activity by decreasing the production of COX-2 and proinflammatory cytokines and the release of histamine, and they reduced the severity of inflammatory disorders

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This is especially important for patients who are also using GLP-1 weight loss medications or losing weight