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Unlike oral supplements, which must pass through the digestive system, where enzymes and stomach acid can degrade their potency, transdermal patches bypass this process entirely

As a result, voltage-gated Ca 2+ channels open, allowing Ca 2+ to flow into the cell

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We often recommend this for patients recovering from surgery or those in an intensive "skin remodeling" phase

However, it also turns out to be true that, under normal conditions, dietary intake of glutathione does not allow its direct use: since it is a tripeptide, enzymes in the gastric juices would break it down into its constituent amino acids, forcing our body to consume energy to synthesize it from scratch