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In a cross-sectional study that focused on HPHCs in salivary and urine samples, detected salivary levels of N 1 -nitrosonornicotine (NNN) in e-cigarette users overlapped with those measured in cigarette smokers, but urine levels of NNN were very low or not detectable in e-cigarette users [41]

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The different curing methods include: Flue-curing : Conducted in temperature-controlled barns, promoting sugar caramelization within the leaves, which results in a naturally sweet and mild flavor