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The largest published trial (METAOD006/OPTIONS) randomized 502 adults with obesity to AOD-9604 or placebo for 24 weeks alongside a diet and exercise program

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Baez-Duarte BG, Zamora-Ginez I, Mendoza-Carrera F et al (2012) Serum levels of glutathione peroxidase 3 in overweight and obese subjects from central Mexico