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Other important differences between e-cigarette aerosols and combustible tobacco cigarette smoke in such systems include aerosols condensing in transit tubing (possibly restricting aerosol flow and impeding syringe function) and some concerns with device button activation synchrony (either manually, or automated with a separate robot) with the syringe puffing to ensure the entire puff is activated and delivered (Goniewicz et al., 2014

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Device characteristics include the type of e-cigarette (first generation versus advanced models), voltage or power, and nicotine strength of e-liquids