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Unlike morning dosing, which gets built into the start-of-day routine, evening dosing competes with relaxation, family time, and simple exhaustion

GLP-1 receptor agonists are widely expressed in the brain, playing a role in reward and addiction pathways

The landscape is also shaped by manufacturing capacity concerns: At last weeks Semafor World Economy, Eli Lillys CEO framed new oral pills as a huge scale solution for global supply constraints, saying that no matter how hard we want to try, we cannot reach the planet with traditional injectable treatments.

And while not quite as effective as injectables, it is more accessible for some