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When Tschp tried chronically infusing one version in obese mice, they got an unexpected result: The mice lost weight

Interestingly, single alanine amino acid substitutions of some interacting residues within the TMD had much larger effects on exendin-4 affinity than removal of the first 8 residues of the peptide (exendin (939) 22,31 ), suggesting that peptide ECD and TMD interactions are correlated

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reported that HT patients adhering to anti-inflammatory diets had lower TSH, higher fT4, and reduced BMI, supporting a possible link between dietary inflammation and thyroid hormone balance [170]

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