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Results Dual function of GLP-1 receptor agonist peptide and anti-PCSK9 antibody fusions Based on the critical requirement for a free N-terminus on the GLP-1 peptide for receptor activation 11 , we genetically fused a DPP-4-resistant GLP-1R agonist peptide, similar to the one used in the Fc fusion molecule LY2189265 12 , to either the heavy or light chain variable domain of neutralising anti-PCSK9 antibodies (Fig

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But, clinical trials show that some work better than others