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Additionally, individuals aged 2544 (AOR 0.27, 95% CI: 0.080.90) and 4564 (AOR 0.07, 95% CI: 0.010.39) had significantly lower odds of e-cigarette use compared to those aged 1517

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While much of the focus and difficulty is on patients with advanced disease, numerous studies have shown that patients in the early stages of the disease have a greater therapeutic benefit, and if effective, precise and safe anti-inflammatory therapies can be developed for different phenotypes of COPD, intervening in the early stages of the disease will show greater benefit, preventing disease progression and reducing the burden of disease

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