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They are activated by airflow and in some cases cannot be manually switched off

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According to an April 2020 Drug Fact Sheet by the United States Department of Justice and the Drug Enforcement Administration titled Depressants, the common depressants are barbiturates (Fiorina, phenobarbital, Pentothal, Seconal, and Nembutal), benzodiazepines that have sedative properties (Valium, Xanax, Halcion, Ativan, Klonopin, and Restoril), and non-benzodiazepine sedative-hypnotics (Lunesta, Ambien, and Sonata)

An independent Data and Safety Monitoring Board (DSMB) will be appointed for this study