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5-12 However, in clinical trials, including SURMOUNT-1 for tirzepatide and STEP 1 for semaglutide, participants were permitted to remain on a given dose for up to 4 additional weeks, as needed, to allow for the dissipation of any GI AEs

The prescribing information for both medications specifically advises against combining GLP-1 receptor agonists

Life changes, metabolic adaptation shifts, and seasonal patterns all affect your weight trajectory

He did not have diabetes or thyroid disease

The GIP activation adds metabolic benefits that pure GLP-1 agonists like semaglutide do not provide, including enhanced fat oxidation and improved lipid metabolism