At 68 weeks, the 12 mg dose delivered 28.7% average body weight reduction, approximately 71.2 pounds from a starting weight of about 248 pounds
The mechanism centers on TREK-1, a two-pore domain potassium (K2P) channel widely expressed in the central nervous system
Initially registered on April 19, 2022, it has never been inspected by the FDA
Administration of MPTP or rotenone in mice promotes the development of mitochondrial dysfunction via inhibition of mitochondrial complex I, suggesting that inhibition of mitochondrial complex I and propagation of mitochondrial dysfunction could be the primary event in PD neuropathology
Moreover, mitochondrial damage elevates ROS levels (380), which can in turn damage mtDNA and proteins that may be involved in the electron transport chain (ETC), resulting in lowered ATP production and decreased energy levels (381)