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But this same long half-life creates an accumulation effect
Recently, the FDA cataloged the KCCQ as a primary endpoint (clinical outcome assessment) for clinical trials.22 The PRESERVE-HF23 study, investigating dapagliflozin use in HFpEF (324 patients, 12-week follow-up), demonstrated improvements in the symptoms, physical limitations, and functional capacity related to the disease
Additionally, they suppress glucagon secretion , slow gastric emptying, and promote satiety through central nervous system pathways, which collectively improve glycaemic control and facilitate weight loss
To avoid this discomfort: Replace spicy dishes with milder seasonings like basil, oregano, smoked paprika, cumin, or turmeric
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