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Furthermore, GLP-1RAs alleviate inflammation by decreasing the levels of TNF-, IFN-, MMP-9 and other pro-atherogenic factors, thereby slowing the progression of atherosclerosis 44

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Common issues include claims of lack of medical necessity or the drug not being included on the insurance formulary

Ozempic and Rybelsus , while officially approved for type 2 diabetes, are also sometimes prescribed off-label to support weight loss

[89] In May 2026, the CHMP adopted a positive opinion, recommending a change to the terms of the marketing authorization for the medicinal product Wegovy