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These subclusters exhibited the highest expression of ARX and DNMT1 , suggesting that these subpopulations represent the most mature cell subclusters (Figure 3E
As hHGF is known to induce the branching morphogenesis 22,26,31 that builds epithelial architectures during embryogenesis, we finally examined whether the dimeric macrocycles could stimulate the formation of tubules in a population of RPTEC
Effects studied in this space are mediated through specific enzymatic pathways rather than one mechanism, and the pharmacology is described in the peer-reviewed literature