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Elevated levels of liver enzymes gamma-glutamyl transpeptidase (GGT), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) can indicate liver damage, as can elevated serum bilirubin (a breakdown product of the red blood cell component hemoglobin normally cleared by a healthy liver)

Melatonin Melatonin is an amphiphilic molecule that has been identified as a potent antioxidant therapeutic agent in neurodegenerative diseases (Polimeni et al., 2014) associated with mitochondrial dysfunction (Ganie et al., 2016) (Table 1)

e Stool examination, biopsy, endoscopic retrograde cholangiopancreatography, ultrasonography, or computed tomography

For patients with GI conditions that limit absorption, the difference is especially pronounced

Most research-community protocols cap on-time at 4-6 weeks with at least equal time off between cycles