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Chronic inflammation is a root cause in the progression of many chronic illnessesfrom neurodegenerative diseases like Alzheimers and Parkinsons, to autoimmune conditions like psoriasis, and metabolic syndromes like diabetes and obesity
Gating strategy was shown in Supplementary Fig
When NAD+ is depleted, ATP production suffers and fatigue results
Different studies have shown that vitamin C acts as a multiorgan targeting agent and can play a role in epigenetic level, regulation of kinase activity, inhibition of epithelialtomesenchymal transition (EMT), immunoregulatory effect, increasing oxygen sensation, prooxidant activity, etc
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