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A single-nucleus transcriptomic atlas of primate testicular aging reveals exhaustion of the spermatogonial stem cell reservoir and loss of Sertoli cell homeostasis

The persistent inflammatory environment not only exacerbates oxidative stress but also promotes the recruitment and activation of additional immune cells, further perpetuating the autoimmune response [58]

Erythrocytes are filled with iron-containing hemoglobin, prone to oxidative stress, critical for ferroptosis, and contain GPX4, an important regulator of ferroptosis [78, 498]